Effects of Oleanolic Acid on Myocardial Injury in Diabetic Mice by Regulating Phosphatidylinositol 3 Kinase/Protein Kinase B/Glucose Transporter Type 4 Signalling Pathway

One of the leading causes diabetes-related deaths is myocardial damage, which may be cause heart failure in people with type 2 diabetes mellitus. The objective research was to look at impact coronary kind a pair This project aimed explore protective oleanolic acid on damage mellitus and investigate connected mechanism. Specific pathogen free grade db/db male mice were elected as model, while Db/m opted for control. Different doses drug intervention performed general condition, cardiac function, blood glucose, lipids, degree injury, oxidative stress examined by morphological examination tissues, biochemical examination, gene protein amount detection. results showed that lactate dehydrogenase, creatine kinase isoenzyme, total cholesterol, triglycerides malondialdehyde levels serum Db/db increased, phosphatidylinositol 3 kinase, B, glucose transporter 4 expression superoxide dismutase level tissue decreased. After using acid, concentrations declined mice, rised. recommend has muscle injury conjointly mechanism could also correlated promoting activation kinase/protein B/glucose signal transduction.